Encorafenib is a medication used for the treatment of certain melanoma cancers. It is a small molecule BRAF inhibitor  that targets key enzymes in the MAPK signaling pathway. This pathway occurs in many different cancers including melanoma and colorectal cancers.

The most common (≥25%) adverse reactions include fatigue, nausea, diarrhea, vomiting, abdominal pain, and arthralgia.